IKBKG CLIA Kit for Bovine(Bos taurus) | EIAab.comIKBKG CLIA Kit for Bovine(Bos taurus)

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IKBKG (Gene name),

NF-kappa-B essential modulator (Protein name ), NEMO_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IKBKG(NEMO);

Protein name:

NF-kappa-B essential modulator(NEMO);

Alternative:

Inhibitor of nuclear factor kappa-B kinase subunit gamma(I-kappa-B kinase subunit gamma;IKK-gamma;IKKG;IkB kinase subunit gamma);IkB kinase-associated protein 1(IKKAP1);NF-kappa-B essential modifier;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Interacts with COPS3, CYLD, NALP2, TRPC4AP and LRDD. Interacts with ATM; the complex is exported from the nucleus. Interacts with TRAF6. Interacts with TANK; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Interacts with ZFAND5. Interacts with RIPK2.

Function:

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

419

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

419:

QYQAPDIDTL | QIHVMECIE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q95KU9

String:

Q95KU9

Pfam:

PF11577

UniGene:

Bt.98727

KEGG:

bta:281855

Uniprot:

Q95KU9

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ELISA Kit for Bovine NEMO

Cat.:

E9868h

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96T

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ELISA Kit for Bovine NEMO

Cat.:

E9868m

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96T

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ELISA Kit for Bovine NEMO

Cat.:

E9868r

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96T

ELISA Kit for Bovine NEMO

Cat.:

E9868b

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96T

CLIA Kit for Bovine NEMO

Cat.:

U9868m

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Packing:

96T

CLIA Kit for Bovine NEMO

Cat.:

U9868b

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Packing:

96T

CLIA Kit for Bovine NEMO

Cat.:

U9868r

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Packing:

96T

CLIA Kit for Bovine NEMO

Cat.:

U9868h

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Packing:

96T

Polyclonal Antibody for Bovine NEMO

Cat.:

P9868Rb-m

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40ug/0.2ml

Polyclonal Antibody for Bovine NEMO

Cat.:

P9868Rb-h

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40ug/0.2ml

Monoclonal Antibody for Bovine NEMO

Protein for Bovine NEMO

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤6.8%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤9.2%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of NEMOinto serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	96	89-102
Plasma	97	91-105

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of NEMO and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	90-103%	92-102%	89-104%	91-107%
EDTA plasma(n=5)	93-101%	94-100%	90-103%	89-106%
heparin plasma(n=5)	92-103%	91-105%	94-101%	93-102%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha."
Rottenberg S. , Schmuckli-Maurer J. , Grimm S. , Heussler V.T. , Dobbelaere D.A.E.
Gene299:293-300(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBUNIT OF THE IKK COMPLEX
2.

"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P. , Sonstegard T.S. , Keele J.W. , Heaton M.P. , Clawson M.L. , Snelling W.M. , Wiedmann R.T. , Van Tassell C.P. , Smith T.P.L.
BMC Genomics6:166-166(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
3.

NIH - Mammalian Gene Collection (MGC) project
Submitted (2007-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Hereford.
tissue: Fetal skin.

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